Dynamic changes in neutrophil activation and metabolic profile during pregnancy are associated with gingival inflammation
Fecha de Publicación: Octubre 2025 Referencia https://www.nature.com/srep/ Resumen general Neutrophils are key players in both periodontal and placental immunity, undergoing profound immunometabolic and functional changes during pregnancy. Their excessive activation has been linked to gestational complications. Gingivitis, and even more so periodontitis, the advanced stage of this condition, are chronic inflammatory diseases that frequently worsen during pregnancy and have been associated with adverse outcomes
Gingival crevicular fluid from pregnant women impairs trophoblast cell function and trophoblast-neutrophil interaction
Fecha de Publicación: Agosto 2022 Referencia AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. ED. WILEY-BLACKWELL PUBLISHING, INC. Londres. Vol. 88, Nº 2. Resumen general Problem: A strong association between periodontitis and higher susceptibility to pregnancy complications like preeclampsia has been reported although the mechanisms remain elusive. Trophoblast cells modulate the recruitment and functional shaping of maternal leukocytes at early stages to sustain an antiinflammatory microenvironment and